Careers

  • Imagine working for a company that is working to go beyond treating the symptoms of genetic disease by trying to stop its progress at its underlying cause.
  • That’s what we do every day at Lexeo Therapeutics.
  • We’re not content to simply make better therapies – we want to change the arc of medicine. That passion drives us, and we look for it in every person we bring to our team.
  • Ready to be a part of it? See our openings below.

COMPANY BENEFITS:

Health Insurance & Wellness benefits

  • Health, dental and vision benefits
  • Flexible Spending Account (FSA)
  • Health Savings Account (HSA)
  • Disability insurance
  • Life insurance
  • Mental health benefits

Perks & Discounts

  • Commuter benefits
  • Tech stipend
  • Stocked kitchen
  • In office lunch stipend

Retirement & Stock option benefits

  • 401(K) with company match
  • Performance bonus
  • Company equity

Vacation & Time off benefits

  • Unlimited PTO
  • Paid holidays
  • Paid parental leave

Clinical Development

Senior Clinical Trial Manager

  • Hybrid / Contract
  • New York, New York, US
The Senior Clinical Trial Manager (Sr. CTM), in collaboration with the clinical operations program leader, will define local clinical operations strategy and be responsible for country and global execution of complex clinical trials end-to-end consistent with the clinical plan. The Sr. CTM will be responsible for partnering with internal and external business functions and vendors throughout the life cycle of one or more clinical study(ies)in accordance with company SOPs, ICH/GCP, and all applicable local regulations. Candidates for this role must champion a culture of quality and continuous process improvement. 

Primary Responsibilities

  • Manage and lead the day-to-day operations of assigned study(ies) to ensure completion per established program goals. 
  • Effectively manage study timelines, budget, and deliverables so milestones are met on time and within budgeted forecast.  
  • Support and own the establishment of the clinical trial budget and coordinate with CRO(s) and finance colleagues to forecast and track the financial status of the program against approved budget. 
  • Manage and lead cross-functional teams and ensure vendors (e.g., CROs, labs, etc.,) are compliant with the contracted scope of work and budget. 
  • Lead contract research organization (CRO) and vendor selection, and where applicable manage all interactions and deliverables from relevant CROs. 
  • Perform ongoing vendor management and oversight during the study, including review of performed work against budget, negotiation of scope of work, budget amendments, performance management and issue resolution in close collaboration with the Head of Clinical Operations and Project and Portfolio organization.  
  • Review and contribute to operational plans including risk-based approaches to site monitoring, fit for purpose strategies for patient recruitment and retention, patient diversification targets, vendor and site reporting requirements, risk identification and mitigation strategies, trial budgets, site selection, and clinical supplies management. 
  • Ensure inspection readiness at all times. 
  • Author, audit and/or edit documents, relevant training materials and presentations necessary for study initiation and execution; ensure other documents and manuals (pharmacy, laboratory, and operations manuals/plans) are sufficiently clear and available for study initiation and execution. 
  • Ensure appropriate reporting, documentation, completion, and finalization of any corrective and preventive action plans resulting from audits and inspections. 
  • If required coordinate/provide input to Regulatory Affairs for responses to study questions or issues from Health Authorities. 
  • Coordinate responses to study related questions or issues from IRBs/IECs. 
  • Accountable for the overall integrity of the TMF for each respective trial. 
  • Ensure study adherence to ICH/GCP/FDA regulations and SOPs. 
  • Other clinical operation activities that are delegated by Clinical Operations Leadership. 

Required Skills & Qualifications

  • BA/BS degree with 5 plus years clinical trial management experience required. Advanced degree preferred. 
  • Strong knowledge of ICH/GCP/FDA regulations site monitoring/CRA experience is required. 
  • Must have global clinical / registrational trial experience, working with vendors and/or CROs, and planning operational activities. 
  • Experienced working on rare disease trials –Gene & Cell Therapy experience a plus. 
  • Proven clinical study management skills, and experience across operational aspects of all stages of clinical studies, including the global clinical trials.  
  • Strong project management and leadership skills; Excellent organizational and time management skills with attention to detail; Effective communication and interpersonal skills; Problem-solving ability and a proactive mindset; High degree of professionalism and integrity. Experience with Veeva eTMF, SharePoint, Word, Medidata RAVE or other EDC systems preferred. 
  • Must be proficient in spreadsheet development (e.g. Excel) for overseeing clinical trial operations, to generate clinical trial insights/metrics and budget management. 
  • Must be willing to travel to New York City office and to clinical trial sites as required (~10%). 

$0 - $0 a year

LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization.  

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

G&A

General Opportunity

  • Onsite / Full time
  • New York, New York, US
We're always on the lookout for talented people who are excited about what we’re building at Lexeo Therapeutics. If you don’t see a role that fits your background, but feel like you could add value to our team, we’d love to hear from you!

This is an open application for any future opportunities across the organization, including internships.

What We're Looking For:
- Passion for our mission and values
- Strong communication and collaboration skills
- A proactive mindset
- Curiosity and willingness to learn

What You Can Expect:
- We’ll review your application and keep it on file to be considered for current or future openings
- If there’s a potential match, we’ll reach out to start a conversation
- It may take a while for any relevant roles to be available. Please continue to keep an eye on our careers site as well for any opportunities that may align with your experience

We appreciate your interest!

$64,350 - $400,000 a year

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March 2024 announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

Pre-clinical

Postdoctoral Fellow – Cardiac Drug Discovery

  • Onsite / Intern
  • San Diego, CA, US
Lexeo Therapeutics is seeking a Postdoctoral Fellow to join our Discovery & Translation team in San Diego, CA. The individual in this role will play a critical role in the discovery and development of novel therapeutics by supporting therapeutic design, in vitro screening, and sample analysis. The ideal candidate will have a strong background in cellular and molecular biology with some experience in analyzing complex datasets. This is a hands-on laboratory role with the opportunity to guide research strategy.  

Primary Responsibilities

  • Lead and drive drug discovery efforts through the use of computational and informatics approaches 
  • Support the design and execution of in vitro screening studies to advance drug discovery efforts   
  • Coordinate and analyze RNA-seq datasets in support of drug discovery 
  • Employ a variety of cellular and molecular assays, (e.g. imaging, qPCR/ddPCR, western blot, MSD) to support drug discovery efforts 
  • Analyze and interpret data from in vitro studies to provide recommendations to internal stakeholders 
  • Collaborate within and across teams to advance drug discovery and development projects 
  • Maintain current, detailed documentation of experimental designs, results, and analyses using an electronic laboratory notebook  

Required Skills & Qualifications

  • Ph.D. in Biology, Biomedical Sciences, Bioinformatics, Computational Biology, or related field with 0-3 years of post-graduate research experience 
  • Knowledge and experience using bioinformatics workflows 
  • Experience with RNA-seq analysis, including QC, normalization, and differential expression analysis 
  • Hands-on experience with a variety of cellular systems; experience with cardiomyocytes is a plus 
  • Deep knowledge of cellular and molecular biology techniques (e.g.flow cytometry, imaging, RNA/DNA isolation, ddPCR, western blot) 
  • Must be able to effectively document research efforts in an electronic laboratory notebook  
  • Excellent communication, presentation, and project management skills with the ability to effectively convey scientific findings to key internal stakeholders 

$0 - $0 a year

LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization.  

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment. 
Apply now