Careers

• San Diego, CA, United States

• Full Time

• Experienced

About Lexeo 

Lexeo Therapeutics is a New York City-based, clinical-stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer’s disease programs. 

Primary Responsibilities 

• Lead and contribute to the design, execution, and interpretation of experiments to validate novel drug targets. 
• Oversee design and screening of new AAV constructs for discovery  
• Develop and optimize assays and screening strategies to characterize lead gene therapy candidates.  
• Collaborate with cross-functional teams to advance drug discovery and development projects. 
• Analyze and interpret data from in vitro and in vivo pharmacology &safety studies. 
• Research latest scientific trends and technological advances in gene therapy. 
• Design and oversee preclinical studies to evaluate the efficacy and safety of candidate therapeutics. 
• Contribute to the preparation of regulatory documents, including IND submissions. 
• Mentor and supervise junior scientists in a cross-functional setting. 
• Present research findings at internal meetings, scientific conferences, and in peer-reviewed publications. 

  Required Skills & Qualifications 

• Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field. 
• 5+ years of post-Ph.D. experience in a biotech/pharma setting, with a focus on gene therapy research.  
• Drug Discovery for gene therapy or nucleic acid medicines  
• Familiar with AAV gene therapy design and development   
• CRO management for conducting in vivo research studies  
• Designing in vivo gene therapy studies and dosing  
• Experience in biodistribution studies and pharmacology related to gene therapy applications.  
• Gene therapy assay development   
• Designing IND-enabling studies is a plus.  
• Deep understanding of molecular biology techniques (RNA/DNA isolation, ddPCR, RNAscope, western blot)  
• AAV vector design, titering, dosing  
• Expertise in in vivo models for biodistribution and pharmacology studies.  
• Strong analytical skills and proficiency in statistical data analysis.  
• Excellent communication and project management abilities.  
• Graphpad, excel etc.   

Anticipated Salary Range

Depending on qualifications and overall experience, base salary is likely to $150,000 - $190,000 per year. 

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment. 

Apply now

• New York, NY, United States

• Full Time

• Experienced

Role Summary

The Vice President of Business Development will report to the Chief Business and Legal Officer and will lead the articulation and execution of the Company’s business development strategy.  This individual will lead a team that partners across the organization on critical initiatives in support of Lexeo’s business development strategy, and will be responsible for driving transaction sourcing, due diligence processes, and aiding in the negotiation and execution of strategic transactions.  The successful candidate will have a track record of impactful business development transactions and a network of professional industry relationships that will facilitate dialogue and partnerships that further the Company’s goals.  In addition, this colleague will partner with the Program Management team in support of the Company’s Alliance Management activities. 

Location

Our work culture is a hybrid model with days in the New York City office and days working from home.   We welcome applications from candidates located across the Northeast and Mid-Atlantic. A remote working model may be considered for exceptional candidates.

Primary Responsibilities

• Develop and oversee the execution of  Lexeo’s partnering strategy working closely with other team members to identify and deliver on potential business development opportunities 
• Run the full life cycle of a transaction: 
  • Develop and execute on an outreach strategy to prospective partners 
  • Manage a cross-functional team throughout transaction cycle 
  • Coordinate high quality opportunity assessments and due diligence reviews 
  • Lead structuring, negotiation and execution 
  • Work closely with legal counsel on drafting and negotiation of term sheets and agreements 
  • Deliver compelling, audience-specific scientific & business presentations 
  • Enable and lead robust decision-making 
• Establish highly effective relationships with internal stakeholders and senior management 
• Work in conjunction with the Vice President of Program Management to lead alliance management of licensed programs, staying abreast of upcoming deliverables and ensuring that contractual obligations are met 
• Manage, grow and develop the business development team. 
• Be an ambassador for Lexeo at external meetings and conferences to access new opportunities and develop external networks. 

Required Skills & Qualifications

• Minimum 10 years’ experience in the biopharma industry with a demonstrated track record of business development and corporate strategy leadership.  
• Undergraduate education in the sciences and/or finance; advanced degree (PhD, MD) is strongly preferred; MBA is a plus. 
• Ability to understand complex scientific ideas and effectively communicate their value proposition to key internal and external stakeholders; experience within the field of genetic therapies is strongly preferred 
• Extensive experience developing or partnering various types of assets, biotechnology platforms or therapeutic modalities, with companies of varying stage and size  
• Deep understanding of value frameworks and knowledge of financial valuation techniques and ability to perform in-depth analyses of technologies, products, therapeutic areas and companies
• Excellent presentation and communications skills with the ability to compellingly articulate, influence, and work successfully with varied audiences.  
• Ability to prioritize, lead and drive workstreams in a collaborative manner to drive to decision-making on aggressive timelines. 

Anticipated Salary Range

Depending on qualifications and overall experience, base salary is likely to be $300,000-$350,000 per year.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
  Apply now

• New York, NY, United States

• Full Time

• Experienced

Role Summary

Reporting to the Executive Director of Analytical Development and Quality, the Director of Quality Control provides leadership of a scientific team that will execute the development and management of analytical assays related to AAV-based gene therapy programs. This role will also manage the QC testing and release of GMP materials and the oversight of vendors necessary to ensure rapid and efficient turnaround of results or resolving of Quality related issues. This position requires collaborative skills, multi-tasking ability, and desire to strive in a fast-paced environment. As we are an early-stage company, this is a highly visible and impactful role in our organization.

Location

Our work culture is a hybrid model with days in the New York City office and days working from home.   We welcome applications from candidates located across the Northeast and Mid-Atlantic. A remote working model may be considered for exceptional candidates.

Primary Responsibilities

• Responsible for the development and implementation of assays at contract laboratories
• Oversight of technical transfer between laboratories, phase-appropriate validation of assays and QC activities for material release, stability and comparability
• Compile data sets (release and stability, analytical validation) for Regulatory submissions.
• Monitors and manages the life cycle of assigned analytical methods supporting clinical products including oversight of stability programs and reference standards.
• Support characterization and qualification of Reference standards and Control Materials used for all analytical testing
• LEXEO Quality representative with regards to cGMP regulations for manufacturing and testing including deviation/OOS investigation, product impact assessments, change management, and other Quality documentation to address non-conformances at external GxP vendors
• Support Gxp vendor management through LEXEO’s vendor qualification procedures in collaboration with Quality Assurance and conduct routine audits of GxP vendors
• Coordination with internal and external stakeholders, including Process Development, External Manufacturing, Supply Chain, Quality Assurance, Regulatory Affairs, Clinical Supply, Clinical Operations, and Program management
• Manage timely development of assays as well as testing of samples for material release
• Identification and communication of risks in assay performance and their mitigation
• Responsibility to develop, author, review, and/or approve Standard Operating Procedures, specifications, regulatory filing, or other controlled documents as needed
• Provide strategic direction to the organization regarding analytical aspects, e.g. regulations, compliance and current industry best practices
• Provide expertise regarding the development of phase-appropriate testing methodologies to assess strength, potency, impurities, and safety– including such assays for as digital PCR, potency, quantitative PCR, in– for AAV gene therapy vectors, drug substances, and starting materials
• Supporting in-house capability in analytical development for characterization of viral vectors, drug substances, and starting materials

Required Skills & Qualifications

• BS with 10+ years, MS with 12+ years or Ph.D. with 8+ years in chemistry, biochemistry, life sciences, pharmaceutical sciences, chemical engineering or equivalent
• At least 3-5 years of experience in a biotechnology or pharmaceutical company
• Experience in cell and gene therapy products
• Experience with successful drug submissions IND, BLA, etc.
• Experience with pharmaceutical drug-process validation and manufacture
• Strong knowledge of FDA, cGMPs, and ICH guidelines and QBD principles pertaining to analytical development, method validation, technology transfer and quality control testing.
• Cross functional acumen and highly skilled in working with complex issues and creating direction in shifting priorities and ambiguity. Results oriented with breadth and depth in pharmaceutical development and commercial products to resolve complex problems
• Results oriented, has a bias for action. Strong initiative, accountability and willingness to take ownership and drive projects to completion
• Accustomed to “roll up their sleeves” and execute the tasks needed in a small company environment

Anticipated Salary Range

Depending on qualifications and overall experience, base salary is likely to be $175,000-$240,000 per year.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
  Apply now

• New York, NY, United States

• Full Time

• Experienced

Role Summary

The Director, IT and Cybersecurity will provide operational oversight and support for corporate technology, infrastructure, security and the end-user environment. Reporting to the Chief Business and Legal Officer, the Director will oversee the end-user computing environment including laptops, audio-visual systems, the M365 suite, security infrastructure, and other relevant applications.  They will play a both a strategic and tactical role in enabling and maintaining scalable, secure infrastructure and ongoing cybersecurity.  The Director will work with the Managed Service Provider (MSP) to ensure the effectiveness of key processes, including the IT service desk, user lifecycle management, and asset and license management. The ideal candidate will be comfortable working closely with employees and leaders across the organization, and will thrive solving day-to-day problems but also proactively applying a strategic lens to help assess and implement technologies to scale Lexeo’s productivity, efficiency and security.  

Location

Our work culture is a hybrid model with days in the New York City office and days working from home.  This role may require more days in office than remote given the nature of the responsibilities.  Remote work with regular travel to headquarters will be considered for exceptional candidates.

Primary Responsibilities

• Manage the relationship and performance of our MSP, ensuring that they deliver high-quality and cost-effective IT services to our stakeholders. 
• Provide technical support to our end-user communication and consultant network as needed. 
• Work closely with teams across the Company to identify opportunities for process improvement and automation to enhance overall operational efficiency. 
• Coordinate provisioning and maintenance of IT equipment for our employees and contractors, including laptops, printers, communication technologies, etc. 
• Manage IT-related employee workflows for onboarding, job changes, and terminations, ensuring that IT access and assets are granted or revoked promptly and securely. 
• Perform periodic account and access audits of systems and ensure least privilege is enforced. 
• Manage the day-to-day monitoring and operational support of security solution hardware, software, managed solutions, and service provider relationships. 
• Own the development and ongoing improvement of our infrastructure, processes, procedures, and information security program to ensure business continuity and information security. 
• Develop and maintain comprehensive documentation, policies, standard operating procedures, and knowledge base related to IT services and processes. 
• Provide IT and cybersecurity related training, educate on best practices, and communicate changes and updates to management and colleagues. 
• Stay up to date with industry trends, emerging technologies and risks, and best practices to provide recommendations for enhancing our service offerings and infrastructure. 

Required Skills & Qualifications

• A minimum of 8 years’ experience working in IT operations with demonstrated experience leading a very hands-on IT function in a small but rapidly growing company. 
• A minimum of 5 years’ experience in the Biotechnology or Pharmaceutical industry. 
• Expertise in Microsoft technologies and the PC environment 
• In depth knowledge regarding cybersecurity and data privacy concepts and applicable standards and regulations 
• Experience leading and managing IT projects and rolling out IT infrastructures across various technologies 
• Excellent working knowledge of computer systems, security, network and systems administration, databases and data storage systems, phone, and video conferencing systems 
• Strong critical thinking and decision-making skills. 
• Excellent project management skills and strong ability to prioritize 
• Approachable, responsive, and able to proactively communicate risks, issues, and recommendations with a service-oriented mindset 
• Excellent interpersonal, written, and verbal communication skills with the ability to communicate technical guidance and instruction to all stakeholders and team members. 

Anticipated Salary 
Depending on qualifications and overall experience, base salary is likely to be $185,000- $240,000 per year. 

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment. 

Apply now

• New York, NY, United States

• Full Time

• Manager/Supervisor

Role Summary

The Senior Medical Director will have clinical development responsibility for advancing the Company’s Phase 1/2 study of LX1001 for APOE4-associated Alzheimer’s Disease (AD), including serving as medical monitor for the study.  The Senior Medical Director will also be responsible for designing future studies of LX1001, as well as the clinical development strategy for next-generation therapies in the Company’s pipeline for APOE4-associated AD.  Expertise in Alzheimer’s Disease and its mechanisms and the ability to evaluate, interpret, and communicate pre-clinical and clinical data are critical aspects of the role. 

Location

Our work culture is a hybrid model with days in the New York City office and days working from home.   We welcome applications from candidates located across the Northeast and Mid-Atlantic. A remote working model may be considered for exceptional candidates.

Primary Responsibilities

• Oversee all clinical development and strategy aspects of the LX1001 clinical program
• Develop relationships with external experts and advisors
• Lead protocol development and drafting of protocols and amendments
• Oversee conduct of clinical trials including start up, execution, and generation/interpretation of efficacy and safety results
• Ensure clinical support of trials as needed; conduct ongoing medical and scientific review of clinical trial data with cross functional team; manage patient safety reports on trial data to safety and clinical boards; provide input into final analyses and interpretation including the development of the study reports, publications and internal/external presentations
• Present clinical strategy and clinical trial data to management and other internal and external venues
• Participate actively in Regulatory agency interactions, contributing to document generation and participating in meetings with Regulatory agencies
• Cultivate and maintain strong working relationships with key opinion leaders, scientific advisors, and other external experts and stakeholders
• Present clinical strategy and clinical trial data to Company management and external stakeholders, including data safety monitoring boards
• Participate actively in preparation of regulatory submissions, briefing documents, safety reports, BLAs/MAAs, and other regulatory correspondence, and personally participate in regulatory agency interactions
• Provide medical expertise to teams where either general medical expertise is required or where specialty medical input is required
• Liaise with Chief Scientific Officer and CSO Team regarding preclinical and nonclinical activities relevant to corporate pipeline and clinical development strategy
• Perform other duties as required

Required Skills & Qualifications

• Board-certified MD with 10+ years of direct clinical experience
• Specialization in Alzheimer’s Disease and/or industry experience in CNS drug development
• Gene Therapy experience in a biotech company preferred
• Demonstrated ability to think strategically, work independently and be a problem solver
• Highly motivated and accountable, self-directed, and able to execute with attention to detail
• Excellent communication and interpersonal relationship skills including negotiating and relationship management skills across multiple functions and with external stakeholders
• Skilled at leading and motivating teams to prioritize tasks and deliver on deadlines in a highly collaborative and collegial work style
• Patient-focused with a deep commitment to understanding the needs and improving the lives of patients
• Enjoy being part of a growing team and fast-paced environment

Anticipated Salary Range

Depending on qualifications and overall experience, base salary is likely to be $250,000 - $350,000 per year.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
  Apply now