Imagine working for a company that is working to go beyond treating the symptoms of genetic disease by trying to stop its progress at its underlying cause.
That’s what we do every day at Lexeo Therapeutics.
We’re not content to simply make better therapies – we want to change the arc of medicine. That passion drives us, and we look for it in every person we bring to our team.
Ready to be a part of it? See our openings below.
COMPANY BENEFITS:
Health Insurance & Wellness benefits
Health, dental and vision benefits
Flexible Spending Account (FSA)
Health Savings Account (HSA)
Disability insurance
Life insurance
Mental health benefits
Perks & Discounts
Commuter benefits
Tech stipend
Stocked kitchen
In office lunch stipend
Retirement & Stock option benefits
401(K) with company match
Performance bonus
Company equity
Vacation & Time off benefits
Unlimited PTO
Paid holidays
Paid parental leave
G&A
General Opportunity
Onsite / Full time
New York, New York, US
We're always on the lookout for talented people who are excited about what we’re building at Lexeo Therapeutics. If you don’t see a role that fits your background, but feel like you could add value to our team, we’d love to hear from you!
This is an open application for any future opportunities across the organization, including internships.
What We're Looking For:
- Passion for our mission and values
- Strong communication and collaboration skills
- A proactive mindset
- Curiosity and willingness to learn
What You Can Expect:
- We’ll review your application and keep it on file to be considered for current or future openings
- If there’s a potential match, we’ll reach out to start a conversation
- It may take a while for any relevant roles to be available. Please continue to keep an eye on our careers site as well for any opportunities that may align with your experience
We appreciate your interest!
$64,350 - $400,000 a year
About Lexeo
Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs. Lexeo successfully completed a $112M IPO in November 2023 and in early March 2024 announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.
Our work culture for most roles is a hybrid model with days in the New York City office and days working from home. We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Lexeo Therapeutics is seeking a Postdoctoral Fellow to join our Discovery & Translation team in San Diego, CA. The individual in this role will play a critical role in the discovery and development of novel therapeutics by supporting therapeutic design, in vitro screening, and sample analysis. The ideal candidate will have a strong background in cellular and molecular biology with some experience in analyzing complex datasets. This is a hands-on laboratory role with the opportunity to guide research strategy.
Primary Responsibilities
Lead and drive drug discovery efforts through the use of computational and informatics approaches
Support the design and execution of in vitro screening studies to advance drug discovery efforts
Coordinate and analyze RNA-seq datasets in support of drug discovery
Employ a variety of cellular and molecular assays, (e.g. imaging, qPCR/ddPCR, western blot, MSD) to support drug discovery efforts
Analyze and interpret data from in vitro studies to provide recommendations to internal stakeholders
Collaborate within and across teams to advance drug discovery and development projects
Maintain current, detailed documentation of experimental designs, results, and analyses using an electronic laboratory notebook
Required Skills & Qualifications
Ph.D. in Biology, Biomedical Sciences, Bioinformatics, Computational Biology, or related field with 0-3 years of post-graduate research experience
Knowledge and experience using bioinformatics workflows
Experience with RNA-seq analysis, including QC, normalization, and differential expression analysis
Hands-on experience with a variety of cellular systems; experience with cardiomyocytes is a plus
Deep knowledge of cellular and molecular biology techniques (e.g.flow cytometry, imaging, RNA/DNA isolation, ddPCR, western blot)
Must be able to effectively document research efforts in an electronic laboratory notebook
Excellent communication, presentation, and project management skills with the ability to effectively convey scientific findings to key internal stakeholders
$0 - $0 a year
LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization.
LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Principal Scientist/Sr. Scientist – In Vitro Pharmacology Contractor
Onsite / Contract
San Diego, CA, US
Lexeo Therapeutics is seeking a Principal Scientist/Sr. Scientist to join our Discovery & Translation team in San Diego, CA. The individual in this role will be responsible for designing and implementing experiments using iPSC-derived cardiomyocytes or other relevant cell lines to support the discovery and development of novel therapeutics for cardiac disease. This role requires expertise in cell culture techniques, cell differentiation, a strong background in molecular biology, and experience in optimizing high-throughput screening platforms. This is a hands-on laboratory role with the successful candidate also contributing to research strategy.
Primary Responsibilities
Identify relevant in vitro systems to support drug discovery for innovative cardiac targets
Design and optimize protocols for efficient and reproducible differentiation of iPSCs into cardiomyocytes
Design, execute, and interpret in vitro screening studies, including the application of high-throughput screening assays, to advance drug discovery efforts
Employ a variety of cellular and molecular assays, (e.g. imaging, qPCR/ddPCR, western blot, MSD) to support drug discovery efforts
Analyze and interpret data from in vitro studies to provide recommendations to internal stakeholders
Stay up to date on the latest advances in in vitro modeling and consider opportunities toapply novel technologies/techniques for discovery research
Collaborate within and across teams to advance drug discovery and development projects
Maintain current, detailed documentation of experimental designs, results, and analyses using an electronic laboratory notebook
Required Skills & Qualifications
Ph.D. in Biology, Biomedical Sciences, Bioinformatics, Computational Biology, or related field with 0-3 years of post-graduate research experience
Knowledge and experience using bioinformatics workflows
Experience with RNA-seq analysis, including QC, normalization, and differential expression analysis
Hands-on experience with a variety of cellular systems; experience with cardiomyocytes is a plus
Deep knowledge of cellular and molecular biology techniques (e.g. flow cytometry, imaging, RNA/DNA isolation, ddPCR, western blot)
Must be able to effectively document research efforts in an electronic laboratory notebook
Excellent communication, presentation, and project management skills with the ability to effectively convey scientific findings to key internal stakeholders
$0 - $0 a year
LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
