Careers

  • Imagine working for a company that is working to go beyond treating the symptoms of genetic disease by trying to stop its progress at its underlying cause.
  • That’s what we do every day at Lexeo Therapeutics.
  • We’re not content to simply make better therapies – we want to change the arc of medicine. That passion drives us, and we look for it in every person we bring to our team.
  • Ready to be a part of it? See our openings below.

COMPANY BENEFITS:

Health Insurance & Wellness benefits

  • Health, dental and vision benefits
  • Flexible Spending Account (FSA)
  • Health Savings Account (HSA)
  • Disability insurance
  • Life insurance
  • Mental health benefits

Perks & Discounts

  • Commuter benefits
  • Tech stipend
  • Stocked kitchen
  • In office lunch stipend

Retirement & Stock option benefits

  • 401(K) with company match
  • Performance bonus
  • Company equity

Vacation & Time off benefits

  • Unlimited PTO
  • Paid holidays
  • Paid parental leave

Clinical Development

Associate Director, Medical Affairs

  • Hybrid / Full time
  • New York, New York, US
The Associate Director, Medical Affairs is an exciting hybrid opportunity with responsibilities in both Field Medical (approx. 50%) and Medical Affairs HQ. In this role, you will be a trusted partner and extension of Lexeo in the field and a subject matter expert for related scientific communication deliverables.

You will forge relationships with the Medical community and engage in scientific exchange. Your connection to Medical HQ will provide an opportunity to contribute to key strategic deliverables that help inform clinical development plans, advance scientific value of Lexeo’s programs, and address unmet needs.

Note: This role requires approximately 50% travel. We welcome applications from candidates located across North America. The individual will be expected to come into the NYC office on certain days, which can be discussed with the manager.

Primary Responsibilities

  • Identify and foster relationships with key external experts at centers of excellence and other high patient volume settings 
  • Be a trusted scientific partner by conducting scientific exchange to increase the understanding of the scientific and medical value of Lexeo’s program and pipeline. 
  • Develop robust stakeholder engagement plans to gather and consistently communicate key
  • insights that deepen our understanding of unmet needs, knowledge gaps, and therapeutic area landscape. 
  • Develop and deliver presentations to key external stakeholders 
  • Leads high-level stakeholder engagement discussions on medical and clinical topics to advance their understanding of the disease 
  • Leverage clinical data to enhance discussions with external stakeholders that support program and company objectives  
  • Identify opportunities to leverage external experts to achieve Medical Strategy objectives 
  • Support conference strategy and execution by contributing to scientific coverage and external engagement plans 
  • Recommend external stakeholders for critical Lexeo activities such as advisory boards, speaker programs, publications. 
  • Contribute to clinical development plans by identifying research opportunities and trial sites, when appropriate. 

Required Skills & Qualifications

  • Minimum 3 years of MSL experience required  
  • Advanced scientific degree required (i.e. PharmD, NP, PA, MD/DO or PhD)
  • This position requires approximately 50% travel to external meetings, field-based educational events or congresses, and internal meetings
  • Experience in gene therapy, cardiology, and/or rare diseases preferred

$165,000 - $210,000 a year

Base salary dependent on qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

Associate Director, Patient Advocacy

  • Hybrid / Full time
  • New York, New York, US
As the Associate Director of Patient Advocacy, you will play a pivotal role in ensuring that the patient voice is heard and integrated into all aspects of Lexeo’s activities. You will be responsible for developing and implementing strategies to engage with patient advocacy groups and patient communities to understand patient perspectives and address unmet needs. By collaborating closely with cross-functional teams, you will help drive initiatives that prioritize patient-centricity and improve patient outcomes.

Primary Responsibilities

  • Develop and execute a patient advocacy strategy aligned with the company's overall objectives and values.
  • Build and maintain relationships with Global patient advocacy groups to foster collaboration and partnership.
  • Lead patient advisory boards and focus groups to better understand patient diagnostic journey, patient preferences, and educational gaps. 
  • Communicate insights from patient and advocacy group interactions with cross-functional team members to inform program strategies and clinical development plans.
  • Provide guidance and support to internal teams on best practices for engaging with patients.
  • Serve as a liaison between the company and patient communities, ensuring that their perspectives are considered in decision-making processes.
  • Lead the development and implementation of patient-centric initiatives, programs, and resources, such as educational materials and advocacy campaigns.
  • Represent the company at patient-focused conferences, events, and meetings.
  • Collaborate with cross-functional teams, including Medical Affairs, Marketing, Market Access, Regulatory Affairs, and Clinical Development, to ensure alignment and integration of patient advocacy efforts across the organization.
  • Track and measure the impact of patient advocacy initiatives and provide regular updates and reports to senior management.

Required Skills & Qualifications

  • Minimum 3 years of relevant professional experience 
  • Undergraduate degree required
  • Master's Degree in related field (genetics, public health, etc.) preferred
  • Strong track record of developing and supporting successful patient advocacy strategies and communications with excellent written and oral communication skills 
  • Experience in gene therapy, cardiology, and/or rare diseases preferred

$163,000 - $195,000 a year

Base salary dependent on qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

Senior Medical Director, Clinical Development – Alzheimer’s Disease

  • Hybrid / Full time
  • New York, New York, US
The Senior Medical Director will have clinical development responsibility for advancing the Company’s Phase 1/2 study of LX1001 for APOE4-associated Alzheimer’s Disease (AD), including serving as medical monitor for the study.  The Senior Medical Director will also be responsible for designing future studies of LX1001, as well as the clinical development strategy for next-generation therapies in the Company’s pipeline for APOE4-associated AD.  Expertise in Alzheimer’s Disease and its mechanisms and the ability to evaluate, interpret, and communicate pre-clinical and clinical data are critical aspects of the role.

Primary Responsibilities

  • Oversee all clinical development and strategy aspects of the LX1001 clinical program
  • Develop relationships with external experts and advisors
  • Lead protocol development and drafting of protocols and amendments
  • Oversee conduct of clinical trials including start-up, execution, and generation/interpretation of efficacy and safety results
  • Ensure clinical support of trials as needed; conduct ongoing medical and scientific review of clinical trial data with cross-functional team; manage patient safety reports on trial data to safety and clinical boards; provide input into final analyses and interpretation including the development of the study reports, publications and internal/external presentations
  • Present clinical strategy and clinical trial data to management and other internal and external venues
  • Participate actively in Regulatory agency interactions, contributing to document generation and participating in meetings with Regulatory agencies
  • Cultivate and maintain strong working relationships with key opinion leaders, scientific advisors, and other external experts and stakeholders
  • Present clinical strategy and clinical trial data to Company management and external stakeholders, including data safety monitoring boards
  • Participate actively in preparation of regulatory submissions, briefing documents, safety reports, BLAs/MAAs, and other regulatory correspondence, and personally participate in regulatory agency interactions
  • Provide medical expertise to teams where either general medical expertise is required or where specialty medical input is required
  • Liaise with Chief Scientific Officer and CSO Team regarding preclinical and nonclinical activities relevant to corporate pipeline and clinical development strategy
  • Perform other duties as required

Required Skills & Qualifications

  • Board-certified MD with 10+ years of direct clinical experience
  • Specialization in Alzheimer’s Disease and/or industry experience in CNS drug development
  • Gene Therapy experience in a biotech company preferred
  • Demonstrated ability to think strategically, work independently and be a problem solver
  • Highly motivated and accountable, self-directed, and able to execute with attention to detail
  • Excellent communication and interpersonal relationship skills including negotiating and relationship management skills across multiple functions and with external stakeholders
  • Skilled at leading and motivating teams to prioritize tasks and deliver on deadlines in a highly collaborative and collegial work style
  • Patient-focused with a deep commitment to understanding the needs and improving the lives of patients
  • Enjoy being part of a growing team and fast-paced environment

$250,000 - $350,000 a year

Base salary dependent on qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

G&A

Equity Administration and Payroll Manager

  • Hybrid / Full time
  • New York, New York, US
The Equity Administration and Payroll Manager will be a key member of the Lexeo general and administrative team that will lead and scale our company’s equity administration function. In this role, the incumbent is responsible for the day-to-day administration of the payroll and equity functions and will work closely with various internal and external partners, such as HR, accounting/finance, legal and related third-party vendors. The Equity Administration and Payroll Manager will be responsible for hands-on, end-to-end, administration of Lexeo’s equity plans (including options, RSUs, ESPP and 10b5-1 plans) and payroll function. 

Primary Responsibilities

  • Day-to-day administration of all aspects of Lexeo’s equity compensation plans, including award issuance, data and insider trading management, participant onboarding and offboarding, interaction with the third-party equity platform provider/broker, and financial reporting support  
  • Prepare and provide information to participants about vesting schedules, eligibility, and other processes by responding to specific questions, driving regular Q&A sessions and preparing training materials as needed 
  • Monitor and facilitate data transfer between equity management system and payroll system to ensure proper payments and recording of taxable events  
  • Identify, develop, and document end-to-end equity process improvements  
  • Collaborate with Lexeo’s accounting/finance, HR, and legal teams to develop and enhance equity compensation policies, plans, and procedures  
  • Assist in the preparation of financial forecasts and budgets related to equity compensation  
  • Ensure compliance with SOX requirements as they pertain to equity compensation  
  • Provide supporting financial statement disclosures as required  
  • Support the implementation of ESPP and 10b5-1 trading programs 
  • Perform monthly, quarterly, and annual reconciliations of records between equity database and general ledger, HR payroll, board approvals, and tax reporting 
  • In collaboration with HR and accounting, process semi-monthly payroll for employees accurately and in compliance with company policies and procedures 
  • Stay abreast of changes in federal, state, and local tax laws and regulations and implement necessary updates to payroll and equity processes and systems to maintain compliance 
  • Assist in the implementation of new HRIS or equity management software as necessary

Required Skills & Qualifications

  • Bachelor's degree in finance, accounting, business administration, or a related field from an accredited college or university  
  • Minimum of 5 years of equity administration and payroll experience  
  • Experience working in a public company environment on payroll and equity taxation, reporting, and compliance  
  • Deep knowledge of various equity instruments and trading plans, payroll processing, and related tax compliance and reporting 
  • Certified Equity Professional (CEP) certification is preferred 
  • Experience with equity plan administration systems and stock transfer agents 
  • Ability to operate with discretion and confidentiality as well as exercise good judgment and integrity in day-to-day decisions

$120,000 - $150,000 a year

Base salary dependent on qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

Executive Assistant

  • Onsite / Full time
  • New York, New York, US
We are seeking a highly organized, detail-oriented Executive Assistant to join the team and uplift the work of the executive team. This includes diligent calendar management, travel coordination, correspondence, expense management, and coordinating and supporting ad hoc administrative projects. The incumbent must be a self-starter and enthusiastic about supporting the executive team. The Executive Assistant will ensure strong team coordination across departments and Executives. We are looking for a candidate who communicates with ease via email and on the phone, can anticipate needs, is highly organized, and is passionate about the company’s mission. 

You will be a strong fit if you enjoy being part of a team with big ambitious ideas and you gain energy from bringing a smooth systematic process to manage the chaos. You are comfortable working in a fast-paced team environment with some level of ambiguity in which decisions are made quickly and support the evolving needs of the business. You are a clear and kind communicator and proactively bring things up to your colleagues that need to be discussed. You are open to new ideas and feel great when you hit or exceed your goals. 

This role requires an in-office presence 5 days a week; dependent on business needs.

Primary Responsibilities

  • Extensive coordination and scheduling of internal and external meetings, conference calls, and video conference meetings, utilizing Outlook and Video Conferencing on behalf of supported Executives  
  • Manageonsite and offsite meetings, including arranging for any catering and document distribution, IT needs 
  • Prioritize Outlook calendar items and resolve calendar conflicts, informing Executive of meeting changes and keeping them on schedule throughout the day 
  • Coordinate set up and clean up of conference rooms  
  • Management of international and domestic travel, meeting coordination, expense reports and logistics for the executive(s), and triaging changes as they arise  
  • Act as the point of contact among executives, employees, clients, and other external partners 
  • Manage information flow in a timely and accurate manner 
  • Support office management needs as they arise 
  • Assist other Admins. in firm-wide tasks when requested 
  • Organize and maintain the filing of relevant documents 

Required Skills & Qualifications

  • A minimum of 8 years of experience, in progressive administrative functions 
  • Previous track record of success in supporting C-suite level executives required 
  • Highly professional phone and written communication skills 
  • Excellent problem-solving capabilities, with timely resolution, demonstrating an ability to work independently with limited guidance and exercise independent judgment, including knowing when to elevate concerns or issues. 
  • Technology savvy and willing to learn new systems in a short time 
  • Highly responsive and able to work on evenings and weekends when needed to support business needs 
  • Self-starter with a willingness to do what it takes to fulfill all relevant work requests and ensure a smooth outcome on matters large and small 
  • Eager, can-do attitude, willing and wanting to learn and take on projects as needed in a dynamic environment 
  • Prior experience in a start-up environment is strongly preferred 
  • Excellent MS Office knowledge 
  • Outstanding organizational and time management skills 
  • Excellent verbal and written communication skills 
  • Discretion and confidentiality 

$90,000 - $115,000 a year

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now