Careers
- Imagine working for a company that is working to go beyond treating the symptoms of genetic disease by trying to stop its progress at its underlying cause.
- That’s what we do every day at Lexeo Therapeutics.
- We’re not content to simply make better therapies – we want to change the arc of medicine. That passion drives us, and we look for it in every person we bring to our team.
- Ready to be a part of it? See our openings below.
COMPANY BENEFITS:
Health Insurance & Wellness benefits
- Health, dental and vision benefits
- Flexible Spending Account (FSA)
- Health Savings Account (HSA)
- Disability insurance
- Life insurance
- Mental health benefits
Perks & Discounts
- Commuter benefits
- Tech stipend
- Stocked kitchen
- In office lunch stipend
Retirement & Stock option benefits
- 401(K) with company match
- Performance bonus
- Company equity
Vacation & Time off benefits
- Unlimited PTO
- Paid holidays
- Paid parental leave
CMC
GxP Quality Lead
- Hybrid / Full time
- New York, New York, US
Lexeo is building the future of cardiac genetic medicine, and we’re looking for a bold, strategic leader to help us get there. As a Senior Director or Vice President, GxP Quality, you will lead the charge in scaling our Quality organization across clinical and commercial manufacturing programs, embedding excellence into every step of our journey from development to commercial launch. You’ll architect a globally compliant, phase-appropriate GxP strategy that empowers innovation while ensuring rigor. You’ll shape systems, guide teams, and drive decisions that keep science at the center and quality at the forefront. This is your opportunity to lead with purpose, influence across functions, and build a culture where accountability, collaboration, and continuous improvement thrive. If you’re energized by challenges, inspired by impact, and ready to help set a new standard in genetic medicine, this is your moment.
Lexeo is seeking an experienced and hands-on senior leader of GxP Quality to be accountable for both leading and operationalizing strategy to scale our Quality organization across clinical development, manufacturing, translational sciences and clinical biomarkers . This individual will be responsible for developing a phase-appropriate, scalable GxP Quality strategy, ensuring compliance with global regulatory standards (e.g., FDA, EMA, ANVISA, ICH), and embedding a culture of operational excellence across the company.
The ideal candidate will bring deep GMP and GCP expertise, strong leadership and communication skills, and the ability to thrive in a fast-paced, development-stage environment while providing strategic oversight and pragmatic solutions that enable innovation.
Key Responsibilities
- Develop and execute a scalable GxP Quality Assurance strategy aligned with Lexeo’s business goals and regulatory expectations.
- Serve as the senior Quality leader across GMP, GCP, GLP, and GVP functions.
- Advise executive leadership on quality risks, mitigation strategies, and inspection readiness.
- Foster a proactive quality culture rooted in continuous improvement, accountability, and operational excellence.
- Build, mentor, and develop a high-performing Quality team that reflects Lexeo’s values of scientific rigor and collaboration
- Establish and maintain a phase-appropriate Quality Management System (QMS) establishing a document hierarchy including a Quality Manual, policies, SOPs and other documents needed to support a virtual gene therapy organization with early and late stage programs. And, also enabling a QMS that can support a registrational study and commercial launch.
- Ensure quality systems effectively support clinical development, pharmacovigilance, all CMC activities, translational sciences, clinical biomarker development, and external partnerships
- Oversee implementation and maintenance of an electronic QMS (eQMS) to support scalability and compliance
- Lead and/or provide leadership support for GCP, GLP, GMP and GVP quality activities, including internal and external audits, vendor oversight, deviation investigations, and quality agreements, health authority inspections.
- Support clinical trial operations by ensuring all aspects of ICH GCP are followed (e.g., protocol adherence, data integrity, and informed consent compliance)
- Oversee early and late phase manufacturing QA activities, including batch record review, product release, and disposition in collaboration with CMC and Technical Operations
- Drive inspection readiness and represent Lexeo during regulatory inspections and partner audits
- Establish procedures for surveying regulatory intelligence and disseminate throughout Lexeo.
- Oversee and management of a risk-based vendor qualification program including performance of external audits, and ongoing compliance monitoring of CROs, CDMOs, testing laboratories, and other GxP service providers
- Ensure robust Quality Agreements and alignment of standards and expectations across all external partners
- Partner closely with Clinical Development, Regulatory Affairs, Technical Operations, Supply Chain, and Research to ensure quality is embedded throughout the product lifecycle
- Serve as the QA representative on governance bodies and cross-functional development teams, ensuring risk-based decision-making and clear communication of quality principles
Quality Leadership & Strategy
Quality Systems Development
Regulatory Compliance
Vendor and Partner Oversight
Cross-functional Collaboration
Qualifications
- Bachelor’s degree in a relevant scientific discipline (Biology, Chemistry, Engineering, or related field); advanced degree preferred
- 12–15+ years of experience in Quality Assurance within the biotech or pharmaceutical industry, with significant exposure to both GMP and GCP environments
- Proven leadership in building and scaling GxP quality systems within a clinical- to commercial-stage setting
- Strong knowledge of FDA, EMA, and ICH regulations and inspection practices
- Experience in regulatory submissions, from IND to BLA, in support of CMC and clinical components
- Experience managing audits, CAPAs, deviations, and regulatory inspections
- Demonstrated success leading external partnerships (CROs, CDMOs)
- Excellent communication, collaboration, and problem-solving skills with the ability to influence across functions and levels
- Strategic thinker who can balance regulatory rigor with Lexeo’s innovative, fast-paced biotech environment
Preferred Experience
- Experience with AAV-based gene therapy or biologics
- Familiarity with global clinical trial operations and pharmacovigilance practices
- Proven ability to lead cross-functional quality teams in a growth-stage organization
$250,000 - $325,000 a year
Compensation is dependent on qualifications and experience.
About Lexeo
LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization
Our work culture is a hybrid model with 2 days/week in the New York City office and days working from home.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now
G&A
Director/Sr. Director, Capital Markets Finance
- Hybrid / Full time
- New York, New York, US
We are seeking a dynamic Capital Markets team member, preferably with a background in investment banking or equity research, to build, and execute, a best-in-class capital markets strategy. This role will be the primary liaison to analysts and investors, while also serving as a trusted advisor to senior leadership on how Wall Street views our strategy, pipeline, and financial performance.
The successful candidate thrives at the intersection of finance, science, and storytelling, translating complex clinical and operational data into compelling investor-ready narratives that resonate with institutional investors and analysts.
Primary Responsibilities
- In partnership with Lexeo leadership, build a world-class capital markets program, overseeing all messaging, external communications, and investor engagement strategy
- Partner with the CEO, CFO, and senior leadership on quarterly earnings, roadshows, analyst days, and capital markets initiatives
- Coordinate preparation of investor-facing materials: earning scripts, Q&A prep, press releases and corporate presentations
- Serve as a spokesperson for the company with institutional investors and analysts
- Monitor sell-side coverage, investor sentiment, peer activity, and sector dynamics to anticipate market reactions
- Build and maintain sophisticated financial models, comps, and valuation scenarios to inform both investor messaging and internal decision-making
- Provide leadership with insights into market opportunities, risks, and investor priorities.
- Prepare and/or deliver investor-informed readouts of clinical, operational, and R&D data to executives and the Board.
- Advise internal teams on framing pipeline milestones, trial timelines, and value drivers for Wall Street.
- Partner with leadership to refine pipeline and corporate strategy through the lens of investor expectations.
- Coordinate quarterly earnings process end-to-end, including script, deck, Q&A prep, and messaging
- Manage investor conferences, non-deal roadshows, analyst days, and targeted outreach programs
- Ensure all external communications comply with SEC and regulatory requirements
- Conduct benchmarking of peers’ pipelines, valuation frameworks, and investor narratives.
- Translate insights into actionable recommendations for internal strategy and external messaging
Required Skills & Qualifications
- Bachelor’s degree in finance, economics, business, or life sciences required; MBA or CFA strongly preferred. Medical or scientific background a plus.
- 7-10 years in capital markets, investor relations, equity research, investment banking, or corporate strategy
- Biotech/pharma experience preferred; must demonstrate ability to interpret and communicate complex clinical data
- Proven track record of direct engagement with institutional investors, analysts and capital markets stakeholders
- Strong financial modeling, valuation, and market analysis expertise
- Exceptional communication and executive presence, with ability to influence both internal leaders and external stakeholders
$200,000 - $250,000 a year
Compensation is dependent on qualifications and experience.
About Lexeo
LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization
Our work culture is a hybrid model with 2 days/week in the New York City office and days working from home.
Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now